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43:52
Nov 16, 2023
Webinars

HiFi Data to Insights: Characterization, AI & More for Accelerated Gene Therapy

Gene therapy has reached a critical point where precision is paramount. Complete AAV genome sequencing not only enhances vector design but also uncovers previously hidden packaging challenges. HiFi sequencing data empowers researchers to identify fragmentation, confirm desired transcript expression, and detect truncations and impurities.

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58:52
Jun 27, 2023
Webinars

Highly accurate HiFi reads for discovery, design, and manufacturing of AAV gene therapy

Gene therapy is at an inflection point and experiencing tremendous growth. High accuracy and complete visibility are critical to the success of novel vector discovery, vector design, and manufacturing quality control for gene therapy products. This webinar illustrates why PacBio HiFi sequencing is the ideal solution due to its ability to sequence full length AAV genomes at high accuracy, which allows for detection of fragmentation, mutations, and large structural events. Short reads, qPCR, and less accurate long-read technology can miss important changes that may be present in the AAV sequence, potentially affecting the safety and efficacy of gene therapy products.

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25:12
May 6, 2024
Webinars

Exploring Validation Studies for AI-Based In Silico Techniques in AAV Gene Therapy

Join Form Bio to delve into the biological study results conducted in collaboration with independent lab partners. This webinar will showcase how FORMsightAI can accurately predict and optimize vector outcomes.

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57:54
Sep 5, 2023
Webinars

Optimizing and Confirming AAV Vector Design with PacBio Sequencing

This bioinformatics webinar explores how to generate and analyze full-length AAV genomic data with PacBio HiFi sequencing: a cutting-edge long read technology for profiling packaged genomes as a single intact molecule, measuring impurities, and verifying that vector capsids contain your intended design. The presenter is PacBio scientist Dr. Elizabeth Tseng and the guest panel consists of research leaders at Homology Medicines and AavantiBio who discuss how, when, and where they use the PacBio AAV sequencing to drive innovation in their gene therapy research programs.

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56:22
May 2, 2024
Webinars

AAV capsid discovery and design – novel sequencing approaches

In this webinar, hear expert testimony about the practical applications of HiFi sequencing in creating novel AAV capsids, highlighting the technology’s impact on safety and efficacy. You’ll also understand the intricacies of AAV whole-capsid engineering and the advantages of PacBio long reads for addressing current challenges. Finally, you’ll discover more comprehensive solutions for vector discovery, design, and characterization, setting new standards in gene therapy research.

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17:52
May 30, 2024
Webinars

ARM Workshop: Utilizing AI/ML for Improved Vector Design and Manufacturability

Workshop On Demand: Join Dr. Anusha Sriraman, PhD, from Form Bio, and the Alliance for Regenerative Medicine at the Advanced Manufacturing for Cell and Gene Therapies Workshop.

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3:12
Oct 12, 2022
Informed Insights

Highly accurate AAV sequencing with PacBio’s end-to-end workflow

PacBio’s AAV end-to-end workflow and flexible protocol allow scientists to comprehensively profile packaged genomes as individual intact molecules to identify potential contaminants that can affect the safety, efficacy, and cost-effectiveness of AAV vector gene therapy.

Stay Informed

Standards for Describing and Analyzing AAV

While long-read sequencing is invaluable for characterizing AAV genomes, it lacks standardized nomenclature and metrics, which makes it difficult to analyze and interpret the data. To address this, we’ve established an AAV Working Group, partnering with academic and industry leaders to set standards aimed at driving improvements in vector design and product quality.

The AAV Working Group has proposed the following standardized nomenclature for making gene therapy collaborations easier and more productive.

AAV Working Group

The AAV Working Group members are leading thinkers and doers in gene therapy, from both academia and industry. Members work with FormBio and PacBio to help shape and contribute to various AAV standards and best practice knowledge sharing.

Adam Cockrell, PhD

Adam Cockrell, PhD

Solid Biosciences
Pranam Chatterjee, PhD

Pranam Chatterjee, PhD

Duke University
Douglas McCarty, PhD

Douglas McCarty, PhD

Nationwide Children’s Hospital
Phillip Tai, PhD

Phillip Tai, PhD

UMass Medical School
Nam Tonthat, PhD

Nam Tonthat, PhD

Asklepios BioPharma
Nadia Sellami, PhD

Nadia Sellami, PhD

PacBio
Elizabeth Tseng, PhD

Elizabeth Tseng, PhD

PacBio
Claire Aldridge, PhD

Claire Aldridge, PhD

Form Bio
Brandi Cantarel, PhD

Brandi Cantarel, PhD

Form Bio
Alpha Diallo, PhD

Alpha Diallo, PhD

Form Bio
Amicia Elliott, PhD

Amicia Elliott, PhD

Form Bio
Eric Talevich, PhD

Eric Talevich, PhD

Form Bio